Have you been experiencing irregular sleep patterns lately? Are your meal times all over the place? If so, you must have noticed fluctuations in your weight, too, right? These issues can indicate a disruption in your circadian rhythm. This is a call for help, as these disruptors are linked to reduced energy expenditure, poor metabolism, hormonal imbalances, and insufficient sleep, all factors of weight management. How might one eliminate these disruptors and reverse some of the damage done? Our editorial team came across a supplement that does exactly that.
Here’s a deep dive into Sync.
What is Sync?
Sync is a metabolism support formula designed to improve clock gene function, which in turn triggers healthy fat-burning and metabolism. This formula, a first of its kind, was developed after scientists discovered that these clock genes control metabolism. The idea is to get the circadian rhythm in order, which will synchronize other health aspects, like sleep, metabolism, and hormone release.
Before we review the list of ingredients, everyone must understand the notion of clock genes and how their functionality might affect overall well-being.
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How does Sync work?
Sync works to activate a group of genes that the creators refer to as the clock genes. Clock genes [1]2] refer to a group of genes that influence the circadian rhythms, or the body’s 24-hour cycles, which affect sleep, metabolism, and hormone release. One of the primary genes in this group, as hinted in its name, is the circadian locomotor output cycles kaput (CLOCK).
This protein is responsible for the formation of BMAL1. Together, the duo activates other clock genes, such as the PER (period) and CRY (cryptochrome), which are crucial for maintaining the circadian rhythm and regulating cellular metabolism.
Metabolism, per one source [3], refers to chemical processes that help the body convert food into usable energy. This process involves combining calories and oxygen to release energy, which fuels our bodily functions. Metabolism encompasses two processes: catabolic and anabolic. Catabolic processes break down molecules to release energy, whereas anabolic processes build up molecules. Examples of catabolic processes include glycolysis and the breakdown of fat, while examples of anabolic processes include protein synthesis and muscle growth.
Typically, morning sunlight triggers the mind and body to become fully awake, activating clock genes and metabolism on full blast. Unfortunately, the combined effects of the Industrial Revolution, man-made barriers, atmospheric pollution, artificial light, and more time spent indoors on the activation process have been negatively impacted. Another source [4] that covered the importance of clock genes added continual food availability and ever-changing work and social demands on our sleep/wake timing to this list of circadian disruptors.
These disruptors negatively impact organs and tissues, causing “catabolic and anabolic processes to be out of sync, leading to pathological consequences [4].” Pathological conditions that might result from a disruption in metabolism include, but are not limited to, muscle wasting, metabolic disorders (such as metabolic syndrome, diabetes, obesity, etc.), and bone density loss.
As long as these processes are in sync, the metabolic rate increases, meaning that more calories are burned at rest rather than being stored as fat, which can lead to healthy weight management.
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What ingredients are in Sync?
The Sync formula consists of the following plants, herbs, and related compounds in a 320mg proprietary blend:
Tulsi
Tulsi [5], or the Holy basil, is a medicinal herb from the Lamiaceae family. Its leaves and purple flowers are considered therapeutic by Ayurvedic practitioners. At the time of writing, studies have reported evidence in favor of its ability to improve metabolic rate, neurocognitive and mood conditions, and immune functions. Regarding metabolic benefits, tulsi can lower blood sugar, improve cholesterol and blood pressure, and decrease inflammation.
One study [6] examined Tulsi’s genes, transcripts, and proteins. This analysis concerns the role of the circadian clock in plant growth and development. The goal was to identify 24 potential core clock proteins, which were all identified. The researchers explained that this successful search is imperative, as “they express during different times of day or form complexes to regulate the expression of other genes [6].”
This might also explain Tulsi’s adaptogenic properties (i.e., helping the body better respond to physical and emotional stress) since clock genes are also involved in sleep, stress, and memory. Finally, some smaller studies have reported that taking Tulsi for four weeks could potentially increase the immune response in adults, but more research is still needed on this [5].
Camellia Sinensis
Camellia Sinensis [7] is a tea plant with a rich source of catechins, caffeine, L-theanine, and other compounds such as vitamins, minerals, and alpha-linolenic acids. Like Tulsi, this ingredient has anti-stress effects, primarily due to L-theanine. Research has shown that the compound might promote relaxation and reduce anxiety by increasing levels of the feel-good hormone, dopamine, and mood-related hormone, serotonin. Regarding weight management, its concentration of EGCG must be highlighted, as it inhibits enzymes that cause the body to absorb and digest carbs and fat from the gut.
Additionally, studies have reported the link between EGCG intake and improvements in gut microbiota and weight loss (i.e., by regulating fat metabolism and breaking down fat). One study [8] investigated the Lhcb gene in tea plants. The researchers identified 16 CsLhcb genes in the tea plant with various cis-acting elements, including hormonal, abiotic stress responses, and light response elements. Why does this matter? As it turns out, the circadian regulation in tea plants influences the production of polyphenols and catechins, can support metabolic health, and exhibits anti-inflammatory effects.
Chlorogenic Acid
Chlorogenic acid (CGA) [9] is a polyphenol popularly extracted from the Camellia sinensis plant. It is considered multidimensional for its anti-inflammatory, antioxidant, and anti-pathogen properties, as well as its neuroprotective effects and ability to mitigate several health conditions. In terms of metabolic health, CGA has been shown to increase AMP-activated protein kinase (AMPK) levels, which are imperative for maintaining and restoring metabolic homeostasis of glucose and fats. MDPI studies state
CPF positively affects circadian rhythm regulation, affects the expression of clock genes, treats metabolic syndrome caused by circadian sequence disorder and improves host microecological health
In other words, it might inhibit pancreatic lipase activity and improve metabolic indexes such as the “fasting serum glucose (FSG) level, glucose tolerance, glucose uptake, insulin sensitivity, and lipid profiles [9].”
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L-Carnitine
L-carnitine [10] is a type of amino acid believed to be involved in metabolism. Specifically, it has been shown to transport fatty acids into the cell’s mitochondria, or powerhouse, where these fatty acids are burned for usable energy. The same source commented on a systematic review of 37 reviews, concluding that L-carnitine reduced body weight and body mass index (BMI) but not necessarily belly fat or body fat percentage. Interestingly, it might reduce belly fat in people with polycystic ovary syndrome. Other benefits include improved markers of learning, healthy heart function, and enhanced exercise performance.
A mice study [11] that looked at the preventative effects of L-carnitine on lipid metabolism and circadian clock of mice subjected to chronic jet lag found that the amino acid decreased levels of glutamic-oxaloacetic transaminase (GOT) and triglycerides. This duo was previously elevated by chronic jet lag. Moreover, quantitative real-time polymerase chain reaction analysis revealed that L-carnitine supplement reversed negative changes in gene expression linked to lipid metabolism, metabolic regulator, and circadian rhythm.
All this is to say that the amino acid might be a fitting candidate to prevent circadian clock disruption. Given the subjects under consideration, more research is needed.
Resveratrol
Resveratrol [12] is an antioxidant-rich plant compound derived from grape skins and certain berries. Due to its antioxidant content alone, studies have found that the compound could lower blood pressure levels by increasing nitric oxide (NO) production, which causes blood vessels to relax. Interestingly, this ingredient decreased total cholesterol levels and body weight when paired with a high-protein, high-polyunsaturated fat diet. Returning to their antioxidant properties, they are critical for decreasing the oxidation of bad cholesterol, which helps prevent plaque buildup in the arteries.
Other mechanisms worth highlighting include resveratrol’s ability to improve insulin sensitivity, protect against oxidative stress, decrease inflammation, and activate the AMPK. A review [13] that covered the modulating effects of resveratrol on the circadian rhythm emphasized how resveratrol achieves circadian regulating effects by activating a protein called SIRT1, thereby increasing Bmall, Per1, and Per2 genes. The researchers further noted that improving insulin sensitivity is also closely related to circadian rhythm disturbances, which resveratrol contributes to.
Finally, a more recent study [14] that looked at the effects of resveratrol in young and older human adipose-derived progenitor cells found that the plant compound does, in fact, impact core clock gene expression in these cells. According to the researchers, this means that resveratrol has the potential to act as a therapeutic agent for longevity.
Chromium (200 mcg)
Chromium [15] is an essential trace mineral for improving insulin sensitivity and turning fats, carbohydrates, and proteins into energy. In fact, people with many conditions linked to insulin resistance (metabolic syndromes and PCOS, among others) have benefited from chromium supplementation. Other benefits include healthy energy and cholesterol levels and some weight loss results, namely reducing body fat and increasing muscle mass.
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Frequently Asked Questions (FAQ)
Q. Who is Sync suitable for?
A. The creators believe that Sync would benefit those who have stubborn fat, feel extremely tired, and have metabolic and sleep problems that need to be reversed. So far, this formula has been tested by over 110,000 men and women between 18 and 80. To date, no one has reported the lack of results or the risk of side effects.
Q. Is Sync safe?
A. Since Sync is 100% natural and is manufactured in an FDA-registered, GMP-certified facility, the creators state the formula is non-GMO, dairy, and soy-free and non-habit forming. However, pregnant and nursing mothers and children under 18 years of age may want to refrain from taking it altogether. As for people with an existing medical issue, the best course of action is to consult with a healthcare provider.
Q. How should I take Sync?
A. For the best possible result, individuals should take each Sync serving (i.e., 2 capsules) with a glass of water first thing in the morning.
Q. What is the estimated arrival time on Sync shipments?
A. Sync shipments to U.S. regions require 7 to 10 business days, while all eligible countries must wait at least 15 business days.
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Q. Does A money-back guarantee protect Sync purchases?
A. Yes, Sync has been protected by a 60-day money-back guarantee. If the first two months of giving Sync a try don’t seem to affect sleep or metabolism, customer service can be contacted for a full purchase price refund. For the specifics of the refund policy, the customer support team can be reached via:
- Email: support@metabo-sync.com.
- Phone: 1 (844) 687-3438
How much does Sync cost?
Each Sync bottle offers users 30 total servings. Since circadian disruptors exist daily, stocking up on Sync supply might be a good idea. To encourage bulk purchases, the creators have landed on three price points:
- 1 Sync bottle: $79 each + applicable shipping
- 3 Sync bottles: $59 each + applicable shipping
- 6 Sync bottles: $49 each + free domestic (U.S.) shipping
Final Verdict
To wrap things up, Sync is a dietary supplement containing plant-based ingredients with clock genes in their genetic makeup. These are essential for their ability to adapt to their environment. Most of the plants found in this formula contain plant compounds formed thanks to their circadian rhythms.
Hence, many of the above-listed ingredients have a positive effect on metabolism, brain function, immune function, and even weight management.
In addition to selecting plants with clock genes in their genetic makeup, the creators found ingredients that reverse the effects of circadian disruptors and improve health markers that upregulate the circadian rhythm.
Our research suggests that each ingredient has a positive role individually, which is reassuring. All in all, Sync has great potential and might be worth testing. As always, individuals are invited to do their own research (accounting for health factors) before getting started.
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